Matters Need to be Paid Attention to after the Kidney Transplant

For the patients of renal failure who have taken the kidney transplant, the operation is not the end point for the treatment. As we all know, the kidney transplant means we need to transplant the kidney of other body into our body, so it is hard to avoid the rejection of the body, which means the immunity system reject the transplanted kidney and attract it. For some serious cases, the rejection may lead to the failure of the kidney transplant, which is rather dangerous. Therefore, there is a series of matters need to be paid attention to after the kidney transplant.

Misunderstanding of the kidney transplant

In recent years, with the development of the kidney transplant technique, there are thousands of patients of end stage of renal failure take the kidney transplant operation and then prolong their lives. For the learning of kidney transplant, there still are some misunderstandings. For example, some people think the kidney transplant is to resection the patient’s kidney then transplant the kidney of other body in the same position of the original kidney. And some patients think the kidney transplant will solve everything and they have nothing to worry about after the operation.

Indeed, kidney transplant is to transplant the donor’s kidney into the fossa iliaca in the right or life abdomen to replace one of the patient damaged kidneys. Usually, the operation doesn’t need to resect the damaged kidney of the receptor. After the kidney transplant, as the strong rejection of the immunity system to the transplanted kidney, most patients have to take the immunosuppressive agent for the whole life.

The function of immunosuppressive agent is to make the rejection to the transplanted kidney weaker. While, at the same time, the immunosuppressive agent also weakens the immunity ability, then the bacterium and infections will threaten the patients’ health due to the weaker immunity. So after the kidney transplant, the patients need to two major problems:

First, pay close attention to prevent the infection

Infections is one the most common and dangerous complications after the operation. During the three months after the operation, the immunity of the patients is the weakest due to the large amount of immunosuppressive agent. And various of bacterium, mould, virus will take advantage of the weak point. The common infections include the upper respiratory tract infection, urinary infection, pneumonia, gastroenteritis, herpes zoster and so on. Due to the poor immunity, and the patients are not sensitive to the antibiotic, so once the patients got infection, it is hard to be controlled.

In order to prevent from infection, hope the patients can pay attention to the following aspects:

1, exam the concentration of the immunosuppressive agent in the blood and then regulate the dosage of it. The large dosage will damage the immunity, while the small dosage will induce the rejection.

2, don’t got the public place where are too many people.

3, pay attention to the dietetic hygiene and avoid the stale and raw or cold food.

Second, the lifelong anti-rejection

After about half a year of various dangers, the patients may back to work and take proper business. With the decrease of the dosage of the immunosuppressive agent, the patients’ immunity will recover. At this time, the patients need to pay attention to the chronic rejection. The symptoms of chronic rejection can be reduced as “three highs and one low”: high level of creatinine, blood pressure and temperature and low level of urine volume. And there are the proteinuria, pain of the kidney and joint.

As there is no medicine can reverse the chronic rejection, the prognosis of the patients will worse once the chronic rejection started.

So it is important to make the good precaution of the chronic rejection.

1, follow the doctor’s advice strictly and don’t reduce the medicines by oneself. Reducing the medicine by oneself is the main cause for the chronic rejection.

2, avoid the over working, staying up late, catching cold, because virus and bacterial infections all can induce the chronic rejection. The patients who have taken the kidney transplant should develop the habit of taking a nap, which can guarantee of the blood supply of the kidney.

3, avoid the medicines that are harm for the kidney, such as gentamicin, kanamycin, neomycin and so on. And patients had better not inoculate the virus vaccine adjuvant.

4, be a good nurse for yourself. Observe the weight, blood pressure, urine volume regularly.

Indeed, kidney transplant is a complex and dangerous operation. If the patients still have other chance or opportunity, they should avoid the kidney transplant. This should be the last choice for the patients.

Can Patients with Diabetes Receive Kidney Transplant

In recent years, Kidney Transplant success rate has increased greatly for the application of immunosuppressive drugs. For the patients with End Stage Renal Failure, Kidney Transplant is the main replacement therapy for them. However, for the special disease conditions of Diabetes, the patients with End Stage Renal Failure caused by Diabetes generally are not recommended to receive Kidney Transplant.

1. After Kidney Transplant, the patients need to use a large dosage of adrenal cortex hormonem. It can make it very difficult to control blood sugar.

2. The patients with Diabetes are usually complicated with neurogenic cystitis, which can influence the function of transplanted kidneys.

3. The immunity of the patients with Diabetes is usually very weak. Therefore, it is very likely for them to have infection thus decreasing the success rate of Kidney Transplant.

4. The patients with Diabetes are often accompanied by serious vascular diseases, which can shorten the life expectancy of the patients.

5. The blood vessels condition of the patients with Diabetes is usually bad. It can cause influence on the operation of Kidney Transplant.

6. If the patients can not control their blood sugar very well after Kidney Transplant, it will cause kidneys to fail once again.

Based on some researches, only in rare cases of Diabetes, the patients can live more than 20 years after Kidney Transplant.

Therefore, Kidney Transplant generally is not suggested to the patients with End Stage Renal Failure caused by Diabetes. They should choose treatment that can restore their impaired kidneys and lower high blood glucose at the same time.

Complications After Kidney Transplant

After kidney transplant, the patient is very prone to infection. Three contributive factors are as following. First, the major surgery on blood vessel and urinary system temporarily decrease patient immune ability. Secondly, for kidney failure patients, their absolute immunity is low then normal person. Thirdly, the adoption of immunosuppressive drugs further disturbs normal immune system and makes patient even more prone to Lung infection, urinary tract infection and operation wound infection.

In clinical, post organ transplant infection has become one of the toughest problems challenging doctors and patients. Global data shows that more than 50% patients will suffer from Cytomegalovirus (CMV) infection. Domestic data shows that the infection ratio for kidney transplant alone was 21%, with 29% for Liver transplant, 25% for Heart transplant and 39% for lung-Heart transplant. Consequences of infection could be Acute or Chronic rejection, cardiovascular complications, post-transplant Diabetes and shortened life-span of transplanted kidney.

Cardiovascular complication accounts for the second most dangerous factor after kidney transplant. Data shows that more than 50% mortality of kidney transplanted patients stems from cardiovascular diseases. And, Hypertension and Hyperlipidemia could be the most common cardiovascular complications after kidney transplant.
Digestive system complications include dysfunction of the Liver, upper digestive tract bleed and acute pancreatitis.

Dysfunction of endocrine and metabolism could give rise to Hypercalcemia, Hypophosphatemia, Hyperuricemia, Diabetes, Bone Disease, Sexual Abnormality and Dysfunction of Renal Tubules.

Hematological complications include Polycythemia and change of blood rheology and bone marrow suppression.

The occurrence ratio of tumor after kidney transplant is 2%-25%. The transplanted kidney has cancerous pathological change itself, but this condition is rare. In most cases, there could be a relapse or new occurring of kidney tumor after kidney transplant.

In addition, after kidney transplant, your existing kidneys will gradually shrink and lose function completely. So, once there is failure in your transplanted kidney, there is no other choice but another kidney transplant.

Is Kidney Transplant the only Treatment for Renal Failure

At present, dialysis and kidney transplant are the most common treatment methods for Renal failure. Yes, dialysis and kidney transplant are really very important treatment for patients of renal failure, and kidney transplant has solved the life of many patients or at least it prolongs the life of the patients to some extent. While, is kidney transplant the only treatment for renal function?

For patients with rather poor renal function, kidney transplant may be the best choice for them if they are suitable for this operation and don’t have the contraindications for kidney transplant. Although, at present, babies of several months and elder people of eighty can adopt kidney transplant, the more suitable age for the operation is 13 to 60 years old considering the effects and recovery for the operation. Of course, if the patients’ condition is allowable, this limitation can be extended properly. But when the patients are older than 55 years, the complications of the operation will increase and the risk will increase. For the patients with Hepatitis B and Hepatitis C, they need to take treatment for them. And after one month after the recovery of the liver function the patients can adopt kidney transplant. And patients with the following disease are not suitable for kidney transplant: mental disease, chronic respiratory function failure, heart failure, coagulation system disorders and so on. Besides, patients with serious coronary disease or some kinds of nephritis and patients with serious polycystic kidney disease accompanied with serious polycystic liver disease need to be cautious for the kidney transplant.



Micro-Chinese Medicine Osmotherapy. The adoption of Micro-Chinese Medicine Osmotherapy effectively protects kidney function from further decline, and creates a favorable environment for damaged cells’ self-repairing, but the recovering of cells by Chinese medicine is relatively fragile and slow. Then stem cell works in two aspects, A) help with repairing damages of other body parts (like blood vessel damages), and this consolidates the favorable environment for damaged cells self-repairing. B). help with repairing these damaged kidney cells, and provide them with necessary materials. Based on restoring functions of damaged cells, the overall kidney function can enjoy an improvement, but his improvement extent is not satisfying, and especially for end stage kidney failure patients.

Live with Kidney Transplant

How long people live with kidney transplant mainly depends on matching quality, the age of donator and working efficiency chance of transplanted kidney.

Matching quality


The key to long-time live is from a kidney which is closest with your blood and tissue, that is expected to the least rejection from you own body. The closer the relation between donator and receptor, the better the matching quality. Generally, kidney from living donators lasts longer than that from dead ones. Therefore the best choice for long-term working of transplanted kidney is from your biological family members, then others who are willing to offer his or her organ, and eventually deceased.

Age of donator


New discovery reveals that kidney transplant lifespan depends on more donator’s age than receptor’s age. For the reason that, aging and renal aging are associated with changes in the genes expressed in the body, and that process of change is lifelong and that a possible new target in improving graft survival should include looking at strategies that may alter programmed aging in donor transplanted kidneys.

Working chance of donated kidney


Working efficiency chance of donated kidney at the set time point is another factor which affects the lifespan with kidney transplant. Here a chart for your reference.

Working efficiency chance	years after transplant
90%	one year
60%	five years
50%	ten years

Form this view, younger patients may need twice or more times of kidney transplant. If the kidneys they received fail, they need to restart their dialysis and go back to waiting list.

Each year the number in waiting list grows in a large degree and many patients who have registered for kidney transplant passed away during their waiting for donator. So patients who are undergoing long-term waiting are advised to look for effective therapies to repair their renal function. As long as you still remain renal function, namely you can perform urination, there is hope for your remedy.

source:http://www.kidneyabc.com        

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