What Are the Causes of Azotemia in Uremia

Azotemia is a common manifestation in Uremia. It refers to the levels of creatinine, uric acid and other non-protein nitrogen levels rise obviously above the normal levels. If uncontrolled, azotemia can cause serious adverse effects for the patients with Uremia. Therefore, it is very important to prevent azotemia. Primarily, it is essential for the patients with Uremia to know the causes of azotemia.

In Uremia, as the kidneys are damaged seriously, the renal blood flow and glomerular filtration rate (GFR) decline obviously, which can affect the excretion function of kidneys. As a result, the nitrogen accumulates in blood stream resulting in azotemia.

Also the complication gastrointestinal hemorrhage of Uremia can aggravate the primary azotemia. On one hand, it can cause the systemic blood volume to decrease thus leading to renal ischemia and affecting the excretion function of kidneys. If the patients can blood flow insufficiency can be corrected in time, the symptoms of azotemia can relive to some extent. On other hand, gastrointestinal hemorrhage can lead to renal tubular necrosis and aggravate the primary kidney damage thus aggravating azotemia.

However, in some cases, if the patients have too much protein at a time. The kidneys can not discharge the metabolic product nitrogen thus leading to transient azotemia. Once they adjust their diet, the patients will recover normal. Therefore, the patients with Uremia should limit the protein intake strictly.

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