FSGS with GFR 17

FSGS is a hard disease to treat and the renal function deteriorates at a very fast speed. How to treat it with GFR 17?

GFR 17 means that FSGS is in stage 4 Chronic Kidney Disease. Without timely control, dialysis or renal transplantation will be required soon. Then, is there alternative therapy to FSGS along with GFR 17?

FSGS is an immune-mediated disorder, in which the immune system attacks the healthy kidney tissues and cells mistakenly. Immune system is a strong protective system in body and it can defeat the foreign pathological substances when they invade body

In FSGS, the foreign bacteria such as upper respiratory tract infection activates the immune system to defeat the infection bacteria. However, for immune dysregulation, the immune system fails to defeat the bacteria or other pathological substances. As a result, these foreign substances may combine with the antibodies to form immune complexes in blood, afterwards, flow into kidneys. To clear up the immune complexes, the body activates an inflammatory response to remove them, thus leading to inflammatory response in kidney. The inflammatory response may attract more and more inflammatory mediator to aggravate the immune injury in kidneys. As a result, the kidney tissues and cells will become sclerotic and finally necrotic finally.

Immunotherapy is the latest therapy for FSGS. The main types of immunotherapy now being used to treat FSGS are as follows:

Monoclonal antibodies

Monoclonal antibodies are very useful in treating FSGS and it is designed to stop the attack to kidneys by suppressing T lymphocytes activation and over-reactive immune response. In this way, it can stop the immune inflammatory response immediately.

Blood purification

Blood purification can remove the metabolic toxins such as creatinine, urea as well as pathological antibodies in blood. It can eliminate the inducing factors of inflammatory response.