What Are the Common Complications of FSGS

FSGS is commonly seen in both children and adults. It refers to a disorder, in which the filters (glomeruli) in kidneys are inflamed. For long-term use of hormone and cytotoxic agents and kidney damage, the patients with FSGS usually experience a series of complications, as follows:

Infection

Infection is commonly seen in FSGS. Proteins are important nutrients and antibodies in body. For massive protein leakage in FSGS, the levels of IgG and complement proteins decrease. As a result, the immunity weakens thus resulting in high risk of developing infections which can cause the relapse of the disease and even threaten the patients’ life.

Malnutrition

Proteins are the main nutrients and they are the major sources of energy for systemic organs and tissues. The patients with FSGS are very susceptible to the experience malnutrition for protein leakages. If the body can not get sufficient nutrients supply, it can cause amyotrophy and slow down the skeletal development. That is why the children with FSGS are shorter than the healthy children of the same age.

Anemia

Proteins are responsible for carrying iron to every part in body. Due to protein leakages, there is no sufficient iron for transporting iron thus resulting in anemia.

High blood pressure

High blood pressure is a common complication of FSGS. It is mainly attributable to two causes. Firstly, the glomeruli can not discharge excess fluid from body thus resulting in increased blood volume. Secondly, for renal ischemia and anoxia, more angiotensin is produced thus contracting blood vessels.

Osteoporosis

Osteoporosis is commonly seen in FSGS for vitamin deficiency. Vitamin D binds to proteins in blood. Some vitamin D will leak into urine along with proteins.